StS No Sesame. All Street. The Happytime Murders is a filthy comedy set in the seedy underbelly of Los Angeles where puppets and humans coexist. Two clashing detectives with a shared secret, one human (Melissa McCarthy) and one puppet, are forced to work together again to solve the brutal murders of the former cast of a beloved classic puppet television show. The action comedy was directed by Brian Henson from a screenplay by Todd Berger.